产品货号：
Z39234
中文名称：
ULK3抗体
英文名称：
Anti-ULK3 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ULK3 Antibody |
| 指标别名 | unc-51 like kinase 3;ULK3 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,FCM |
| 基因名称 | ULK3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human ULK3 Serine/threonine protein kinase which enhances GLI1 and GLI2 transcriptional activity and consequently positively regulates GLI-dependent SHH signaling.May exert this function by promoting GLI1 nuclear localization.Phosphorylates in vitro GLI2,as well as GLI1 and GLI3,although less efficiently. |
| 实际分子量 | 53KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy.In search of potential homologues to Drosophila and human Fu,people have cloned human serine/threonine kinase ULK3 and assessed its ability to regulate GLI transcription factors,mediators of SHH signaling.And ULK3 enhances endogenous and over-expressed GLI1 and GLI2 transcriptional activity in cultured cells,as assessed by GLI-luciferase reporter assay.Besides that,ULK3 alters subcellular localization of GLI1,as assessed by immunofluorescent staining and immunoblotting assays.It is showed that ULK3 is an autophosphorylated kinase and phosphorylates GLI proteins in vitro.Also,ULK3 catalytical activity is crucial for its function in SHH pathway.It is demonstrated that ULK3 is widely expressed and its expression is higher in a number of tissues where Shh signaling is known to be active.The data suggest that serine/threonine kinase ULK3 is involved in the SHH pathway as a positive regulator of GLI proteins. |
| Uniprot ID | Q6PHR2 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:20～100 Immunocytochemistry/Immunofluorescence(ICC/IF) 1:20～100 Flow cytometry (FCM) 1:20 |
相关搜索：ULK3抗体，ULK3单抗，Anti-ULK3 Antibody